Investigating Perampanel Antiepileptic Drug by DFT Calculations and SERS with Custom Spinning Cell

SERS, a clinical practice where medical doctors can monitor the drug concentration in biological fluids, has been proposed as viable approach to therapeutic monitoring (TDM) of antiepileptic Perampanel. The adoption an acidic environment during SERS experiments was found be effective enhancing spectroscopic signal. In this work, we combine experiments, conducted with custom spinning cell controlled conditions, DFT calculations aimed at investigating possible protonated forms DFT-simulated Raman spectra Perampanel accounts for most observed signals, thus explaining role protonation analyte. Our results suggest fostering alkaline drugs.